Suk Joon Yoon,Ning Ning HE,Na Young KIM,Yong-Yeon CHO
申请号：
US15127299
公开号：
US20180303863A1
申请日:
2015.03.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical composition for treating STK11-mutation cancer, containing, as an active ingredient, a material inhibiting a sodium-potassium transport function of Na+—K+ ATPase (ATP1A1) an anticancer drug containing the composition as an active ingredient and a method for screening STK11-mutation cancer therapeutic agent. It was first established that, of cancer cells in which various gene mutations are confirmed, an STK11-mutation cancer cell line, which is confirmed at high frequency, was treated with cardiac glycosides as a material inhibiting a sodium-potassium transport function of Na+—K+ ATPase (ATP1A1), to significantly inhibit the growth of cancer cells. Therefore, the material inhibiting a sodium-potassium transport function of Na+—K+ ATPase (ATP1A1) can be a target for treating SK11-mutation-derived cancer.
