Various approaches to transmitting an ultrasound beam include creating a 3D tissue replica representing tissue intervening between the ultrasound transducer and a target anatomic region； transmitting a ultrasound beam to the target region； measuring the ultrasound beam traversing the 3D tissue replica and arriving at the target region； and based at least in part on the measured first ultrasound beam, estimating a parameter value associated with one or more of the transducer elements for improving ultrasound beam shaping.
