An inbred rice line designated P64-2S is disclosed. The invention relates to the seeds of inbred rice line P64-2S, to the plants of inbred rice line P64-2S and to methods for producing a rice plant produced by crossing the inbred rice line P64-2S with itself or another rice plant. The invention further relates to hybrid rice seeds and plants produced by crossing the inbred rice line P64-2S with another rice plant. This invention further relates to growing and producing blends of rice seeds comprised of seeds of inbred rice line P64-2S with rice seed of one, two, three, four or more of another rice hybrid, rice variety or rice inbred.