Michael Lutteropp,Anne Richter,Andrew Kaiser,Mario Assenmacher,Stefan Miltenyi
申请号：
US16005466
公开号：
US20180280502A1
申请日:
2018.06.11
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides a system that comprises pharmaceutical agents for use in immunotherapy for reducing the side-effects of an antigen-recognizing receptor against antigen-expressing non-target cells in an individual. The system includes an antigen-recognizing receptor that specifically recognizes an antigen on target cells and at least on one hematopoietic cell type in the individual. The antigen-recognizing receptor is exemplified by chimeric antigen receptors (CAR) be expressed on the surface of an immune effector cells. The system also includes hematopoietic cells resistant to recognition of the same antigen by the antigen-recognizing receptor.
