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Substituted 4-phenyltetrahydroisoquinolines, methods for their preparation, their use as drugs, and drugs containing them
专利权人:
サノフイ
发明人:
ハンス-ヨッヘン・ラング,ハンス-ヨッヘン・ラング
申请号:
JP2008531569
公开号:
JP5231229B2
申请日:
2006.09.08
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
The present invention relates to substituted 4-phenyltetrahydroisoquinoline compounds and pharmaceutical compositions comprising them which are excellent inhibitors of the sodium-hydrogen exchanger (NHE), in particular of the sodium-hydrogen exchanger of subtype 3 (NHE-3). As such these compounds are useful in the treatment of various disorders of the renal and respiratory systems such as acute or chronic renal failure, pulmonary complications, biliary function disorders, respiratory disorders such as snoring or sleep apneas and cardiovascular/central nervous system disorders such as stroke. More specifically, the present invention relates to substituted 4-phenyl-tetrahydroisoquinolines defined by the formula I in which R1-R8 are defined herein.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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