YU, Paul, B.,CUNY, Gregory, D.,MOHEDAS, Agustin, H.
申请号：
EP15768638
公开号：
EP3122355A4
申请日:
2015.03.25
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention provides small molecules inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism or diseases, disorders, or syndromes caused by hyperlipidemia.
