AN IL-IB BINDING MOLECULE, IN PARTICULAR AN ANTIBODY TO HUMAN IL-IB, ESPECIALLY A HUMAN ANTIBODY TO HUMAN IL-IB IS PROVIDED,WHEREIN THE CDRs OF THE HEAVY AND LIGHT CHAINS HAVE AMINO ACID SEQUENCES AS DEFINED, FOR USE IN THE TREATMENT OF AN IL-1 MEDIATED DISEASE OR DISORDER, E.G. OSTEOARTHRITIS,OSTEOPOROSIS AND OTHER INFLAMMATORY ARTHRITIDES.