TILLOTTS PHARMA AG;THOMAS BUSER;FELIPE JOSE OLIVERIA VARUM;ANA CRISTINA FREIRE;ROBERTO CARLOS BRAVO GONZALEZ;ABDUL WASEH BASIT;FREDERIC JEAN-CLAUDE GOUTTE
发明人:
ANA CRISTINA FREIRE,ABDUL WASEH BASIT,ROBERTO CARLOS BRAVO GONZALEZ,THOMAS BUSER,FREDERIC JEAN-CLAUDE GOUTTE,FELIPE JOSE OLIVERIA VARUM
申请号：
IL23528314
公开号：
IL235283A
申请日:
2014.10.22
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
A kind of controlled-release formulation delivering the medicament to colon comprising core and coats the coating of the core. The core includes drug and the coating includes outer layer and the layer at least between Jie's what core and outer layer, which is selected from what group as composed by separation layer and internal layer. The outer layer includes to be easy by the mixture of the first polymeric material of colon germ attack and the second polymeric material with pH critical values 5 or more. The internal layer includes the third polymerization material of solvable what intestinal juice or alimentary canal liquid, which is selected from what group as composed by least partly neutral multi-carboxy acid copolymer and non-ionic polyalcohol. In the embodiment that the third polymerization material is non-ionic polyalcohol, which includes at least a buffer and alkali. The separation layer includes the non-ionic polyalcohol of solvable what intestinal juice or alimentary canal liquid. The outer series of strata are directly coated on the what internal layer or the separation layer in the form of coating object, and the first polymeric material which closes in an aqueous medium is formed with the second polymeric material in organic media. The advantages of inventive formulation includes: that can accelerate the release of drug, and reduce or eliminate the influence of food and/or alcohol to what drug release when it exposes what colon.
