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Enteric coated multiparticulate composition with proteinaceous coating for improved storage stability
专利权人:
Zx Pharma; LLC
发明人:
Syed M. Shah,Fred Hassan
申请号:
US14918042
公开号:
US09717696B2
申请日:
2015.10.20
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A storage stable L-menthol composition includes a tablet, caplet, capsule, or sachet dosage form. The dosage form has (a) a plurality of individual cores containing an L-menthol source and at least one pharmaceutical excipient and (b) a proteinaceous coating of a continuous film of proteinaceous material over the individual cores forming a plurality of proteinaceous coated individual cores. The film is effective to substantially prevent L-menthol in the L-menthol source from leaving the individual cores when stored at a temperature of 40 degrees C. and 75% relative humidity for at least 1 day. The dosage form contains an effective amount of the L-menthol source for treating a gastrointestinal disorder.
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