DÉRIVÉS D'IMIDAZOLE ET DE TRIAZOLE LIÉS À UNE PIPÉRIDINE OU THIOMORPHOLINE ET LEURS UTILISATIONS POUR AMÉLIORER LES PROPRIÉTÉS PHARMACOCINÉTIQUES D'UN MÉDICAMENT

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

申请号：

EP19182311.1

公开号：

EP3587411A1

申请日:

2014.11.07

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present invention relates to piperidine or morpholine linked imidazole and triazole derivatives of formula (I), compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhibiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.In formula(I), especially, W is -N= or -CH=, X is -C(R3)(R4)- or -S(O)2-, and n is 0 or 1

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