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Heterodimers of glutamic acid
专利权人:
Inc.;Molecular Insight Pharmaceuticals
发明人:
John W. Babich,Craig N. Zimmerman,Kevin P. Maresca
申请号:
US16156289
公开号:
US10647666B2
申请日:
2018.10.10
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Compounds of Formula (Ia)wherein R is a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl, a C1-C6 substituted or unsubstituted alkyl or —;NR′;R′;,Q is C(O), O, NR′;, S, S(O)2, C(O)2 (CH2)pY is C(O), O, NR′;, S, S(O)2, C(O)2 (CH2)pZ is H or C1-C4 alkyl,R′; is H, C(O), S(O)2, C(O)2, a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl or a C1-C6 substituted or unsubstituted alkyl, when substituted, aryl, heteroaryl and alkyl are substituted with halogen, C6-C12 heteroaryl, —;NR′;R′; or COOZ, which have diagnostic and therapeutic properties, such as the treatment and management of prostate cancer and other diseases related to NAALADase inhibition. Radiolabels can be incorporated into the structure through a variety of prosthetic groups attached at the X amino acid side chain via a carbon or hetero atom linkage.
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