KRISTOPH VAN EMELEN,MARCEL FRANS LEOPOLD DE BRUYN,MANUEL JESUS ALCAZAR-VACA,JOSE IGNACIO ANDRES-GIL,FRANCISCO JAVIER FERNANDEZ-GADEA,MARIA ENCARNACION MATESANZ-BALLESTEROS,JOSE MANUEL BARTOLOME-NEBRED
申请号：
BR0111859
公开号：
BR0111859B1
申请日:
2001.06.13
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -a<；SUP>；1<；/SUP>；=a<；SUP>；2<；/SUP>；-a<；SUP>；3<；/SUP>；=a<；SUP>；4<；/SUP>；- is a bivalent radical wherein one or two of a<；SUP>；1 <；/SUP>；to a<；SUP>；4 <；/SUP>；are nitrogen and the remaining a<；SUP>；1 <；/SUP>；to a<；SUP>；4 <；/SUP>；are -CH-； -Z<；SUP>；1<；/SUP>；-Z<；SUP>；2<；/SUP>；- is a bivalent radical； -A- is a bivalent radical of formula -N(R<；SUP>；6<；/SUP>；)-Alk<；SUP>；2<；/SUP>；- or a 5, 6 or 7-membered saturated heterocycle containing one or two nitrogen atoms； R<；SUP>；1<；/SUP>；, R<；SUP>；2 <；/SUP>；and R<；SUP>；3 <；/SUP>；are each independently selected from hydrogen, C<；SUB>；1-6<；/SUB>；alkyl, hydroxy, halo and the like； Alk<；SUP>；1 <；/SUP>；and Alk<；SUP>；2 <；/SUP>；are optionally substituted C<；SUB>；1-6<；/SUB>；alkanediyl； R<；SUP>；5 <；/SUP>；is a radical of formula wherein n is 1 or 2； p<；SUP>；1 <；/SUP>；is 0, and p<；SUP>；2 <；/SUP>；is 1 or 2； or p<；SUP>；1 <；/SUP>；is 1 or 2, and p<；SUP>；2 <；/SUP>；is 0； X is oxygen, sulfur or -NR<；SUP>；9<；/SUP>；； Y<；SUP>；2 <；/SUP>；is oxygen or sulfur； R<；SUP>；7 <；/SUP>；is hydrogen, C<；SUB>；1-6<；/SUB>；alkyl, C<；SUB>；3-6<；/SUB>；cycloalkyl, phenyl or phenylmethyl； R<；SUP>；8 <；/SUP>；is C<；SUB>；1-6<；/SUB>；alkyl, C<；SUB>；3-6<；/SUB>；cycloalkyl phenyl or phenylmethyl； R<；SUP>；9 <；/SUP>；is cyano, C<；SUB>；1-6<；/SUB>；alkyl, C<；SUB>；3-6<；/SUB>；cycloalkyl, C<；SUB>；1-6<；/SUB>；alkyloxycarbonyl or aminocarbonyl； R<；SUP>；10 <；/SUP>；is hydrogen or C<；SUB>；1-6<；/SUB>；alkyl； and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products
