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Compounds 1 of pyridinediol [3,4-d] derivatives as TRPA1 modulators
专利权人:
GLENMARK PHARMACEUTICALS S.A.
发明人:
KUMAR, SUKEERTHI,THOMAS, ABRAHAM,DHONE, SACHIN VASANTRAO,KHAIRATKAR-JOSHI, NEELIMA,MUKHOPADHYAY, INDRANIL,PATIL, NISHA PARAG,KADAM, ASHOK BHAUSAHEB,DESHMUKH, VISHAL GOVINDRAO,CHIKHALE, RAJENDRA PRAKAS
申请号:
PE2011001707
公开号:
PE20120774A1
申请日:
2010.03.17
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
It refers to a formula compound (I): R1 and R2 are h, hydroxy, hydrocarbon, halide, etc.; Rb is h, hydroxy, cyanogen, halide, halide, etc.; or alternative arilo, non-c5 cycle, such as: thiazole, pidan, pyrazole, pidan, pidan or benzodiazepine; vesh, cyanogen, nitro, nitro, nrxry, Halogen, etc.; RX and ry are h, hydroxy, halogen, hydrocarbyl, acylquine, etc. The most popular compounds are: n - [4 - (2,4-difluorophenyl) - 1,3-thiazol-2-il] - 2 - (1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-piro [3,2-d] pyridin-5-il) acetyl;[4 - [4 - [4]]] - [4 - [4 - [4 - [4 - [4 - [4]]] - [4 - [4-1. Fluorin-4 - (trifluoromethyl) phenyl] - 1,3-thiazol-2-il; - acetyl and others; The compound is a fused pyridinediol derivative, which is used to treat or prevent diseases related to TRPA1. It is a potential receptor modulator of TRPA1 member aSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: R1 Y R2 SON CADA UNO H, HIDROXILO, ALQUILO, HALOALQUILO, ENTRE OTROS; Rb ES H, HIDROXILO, CIANO, HALOGENO, HALOALQUILO, ENTRE OTROS; U ES ARILO OPCIONALMENTE SUSTITUIDO, HETEROCICLOS C5 TALES COMO TIAZOL, IMIDAZOL, ISOXAZOL, PIRAZOL, TIADIAZOL, PIRIMIDINA O BENZOTIAZOL; V ES H, CIANO, NITRO, -NRXRY, HALOGENO, ENTRE OTROS; RX Y RY SON H, HIDROXILO, HALOGENO, ALQUILO, ALQUENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[4-(2,4-DIFLUOROFENIL)-1,3-TIAZOL-2-IL]-2-(1,3-DIMETIL-2,4-DIOXO-1,2,3,4-TETRA HIDRO-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL)ACETAMIDA; 2-(1,3-DIMETIL-2,4-DIOXO-1,2,3,4-TETRAHIDRO-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL)-N-{4-[4-FLUORO-3-(TRIFLUOROMETIL)FENIL]-1,3-TIAZOL-2-IL} ACETAMIDA; 2-(4,6-DIMETIL-5,7-DIOXO-4,5,6,7-TETRAHIDRO-1H-PIRAZOLO [4,3-d]PIRIMIDIN-1-IL)-N-{4-[3-FLUORO-4-(TRIFLUOROMETIL)FENIL]-1,3-TIAZOL-2-IL} ACETAMIDA; ENTRE OTROS. DICHO COMPUESTO ES UN DERIVADO DE PIRIMIDINDIONA FUSIONADO MODULADOR DEL RECEPTOR DE POTENCIAL TRANSITORIO DE LA SUBFAMILIA A, MIEMBRO 1 (TRPA1) UTILES PARA TRATAR O PREVENIR UNA ENFERMEDAD RELACIONADA CON TRPA1
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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