diagnosis and treatment of cancer using anti-LGR7 antibody

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专利权人:

国立大学法人;中外製薬株式会社;東京大学;国立大学法人 東京大学

发明人:

油谷 浩幸,上原 ゆり子,舟橋 真一

申请号：

JP2010544139

公开号：

JP5801557B2

申请日:

2009.12.25

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

With dedicated research, the present inventors discovered that not only the LGR7 gene but also the LGR7 protein are highly expressed in clear cell adenocarcinoma cells of ovarian cancer. Furthermore, the present inventors found that anti-LGR7 antibodies have antibody-dependent cell-mediated cytotoxicity (ADCC) activity and complement-dependent cytotoxicity (CDC) activity against LGR7-expressing cells. From the above findings, the present inventors discovered that the anti-LGR7 antibodies are useful for diagnosis, prevention, and treatment of primary and metastatic ovarian clear cell adenocarcinoma.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/