Universite Claude Bernard - Lyon 1;Universite d'aix-Marseille;Centre Leon Berard;INSERM (Institut National de la Sante et de la Recherche Medicale);Institut Jean Paoli & Irene Calmettes
发明人:
Faget, Julien,Caux, Christophe,Menetrier-Caux, Christine,Nunes, Jacques,Olive, Daniel
申请号：
AU2012233652
公开号：
AU2012233652A1
申请日:
2012.03.29
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.
