The invention relates to an automatic cleaning and water changing device for a culture box, which comprises a plurality of breeding units, a conveying unit and a water changing unit. Each of the breeding units comprises a receiving box, a water inlet, a reinforced water inlet, a drain, and a reinforced drain. The conveying unit comprises a water storage tank, a water pump, a plurality of inlet pipes, a plurality of reinforcing inlet pipes, and a plurality of drainage pipes. The water changing unit comprises an elevator, and a plurality of drainage hoses respectively communicating with the water tank and the reinforced drainage port, wherein one end of the drainage hose is pulled by the elevator to change its vertical height to switch the group water state or the drainage state.一種養殖箱自動清洗換水裝置,包含有複數養殖單元、一輸送單元、以及一換水單元。每一該養殖單元包含一容置箱,一進水口,一加強進水口,一排水口,以及一加強排水口。該輸送單元包含有一儲水箱,一水泵,複數進水管,複數加強進水管,複數排水管。該換水單元包含有一升降機,以及複數分別連通該水箱、該加強排水口之排水軟管,其中該排水軟管之一端係受該升降機牽引改變其垂直高度,以切換組水狀態或排水狀態。