Elisabeth Thérèse Jeanne Pasquier;Anil Koul;Koenraad Jozef Lodewijk Marcel Andries;Jérôme Emile Georges Guillemont
发明人:
Koenraad Jozef Lodewijk Marcel Andries,Anil Koul,Jérôme Emile Georges Guillemont,Elisabeth Thérèse Jeanne Pasquier
申请号：
US11997015
公开号：
US08691800B2
申请日:
2006.07.31
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of Formula (Ia) or (Ib)a pharmaceutically acceptable acid or base addition salt thereof, a quaternary amine thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl； p is 1, 2, 3 or 4； R2 is hydrogen, hydroxy, thio, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formulaR3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl； R4 is hydrogen, alkyl or benzyl； R5 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl； or two vicinal R5 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl； r is 1, 2, 3, 4 or 5； R6 is hydrogen, alkyl, Ar or Het； R7 is hydrogen or alkyl； R5 is oxo； or R7 and R5 together form the radical —CH═CH—N═； Z is CH2 or C(═O).
