BACON, ELIZABETH M.,CHIN, ELBERT,COTTELL, JEROMY J.,KATANA, ASHLEY ANNE,KATO, DARRYL,LINK, JOHN O.,SHAPIRO, NATHAN,TREJO MARTIN, TERESA ALEJANDRA,YANG, ZHENG-YU
申请号：
CA3051588
公开号：
CA3051588A1
申请日:
2018.02.05
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, the compound of formula (I) for use in therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I. Preferred compounds are N-[(2S) -1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino) -3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(phenyl) methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate atazanavir (ATV) analogues substituted by several heterocycles, such as e.g. pyrazole (Rl)； e.g. oxetane (substituent of X2)； e.g. pyridine or pyrimidine (X1)； e.g. piperazine or 3,8-diazabicyclo[3.2.1]octan (X2).
