Bonnie L. Bassler,Howard A. Stone,Min Young Kim,Thomas William Muir,Aishan Zhao
申请号：
US15793090
公开号：
US20180125066A1
申请日:
2017.10.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to compositions comprising QS modulating molecules attached to a surface via a linker. This QS modulator attached surface can then be used to modulate QS, biofilm production, biofilm streamer production and/or virulence factor production. The length of the linker that attaches the QS modulating molecule to the surface as well as the surface coverage density are features that impact QS modulation on surfaces. These QS modulator attached surfaces can be used to treat areas known to contain human pathogens notorious for causing hospital-acquired infections as well as fatal infections that occur outside of health care settings. Other surfaces that can be coated according to embodiments of the invention include abiotic materials, such as intravenous catheters, implants, medical devices, and cooling towers. Preferred microorganisms that can be treated with the compositions of the invention include, but are not limited to S. aureus and/or P. aeruginosa. The QS modulator attached surface also demonstrates exceptional stability.
