The present disclosure relates to a hemodialysis membranefor the treatment of vascular calcification in hemodialysispatients, especially in chronic hemodialysis patients. Thepresent disclosure further relates to methods of treatingvascular calcification in hemodialysis patients, whereinthe hemodialysis membrane is characterized in that itcomprises at least one hydrophobic polymer and at least onehydrophilic polymer and in that it has a MWRO of between 15and 20 kD and a MWCO of between 170-320 kD or that thehemodialysis membrane comprises at least one hydrophobicpolymer and at least one hydrophilic polymer and has a MWRO ofbetween 8.5 kD and 14.0 kD and a MWCO of between 55 kD and130 kD.