A device (32) for removing uremic toxins in a dialysis procedure comprising: a body (40) having an inlet and an outlet and defining an interior, the interior including a first layer comprising zirconium oxide, a second layer comprising zirconium oxide, a zirconium phosphate layer between the first and second layers, and a layer comprising urease. There is also disclosed a method for constructing a cartridge for use in a system for providing dialysis comprising the steps of providing a body having an inlet and an outlet and defining an interior, the interior including a first layer comprising zirconium oxide, a second layer comprising zirconium oxide, a zirconium phosphate layer between the first and second layers, and a layer comprising urease.