The present invention relates to the medical use of specific GLP-1/glucagon receptor agonists in the prevention and/or treatment of metabolic liver disease, particularly non-alcoholic fatty liver disease (NAFLD), more particularly non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH) and/or NAFLD-associated liver fibrosis.本發明關於特定的GLP-1/胰高血糖素受體激動劑在預防和/或治療代謝性肝病,具體地非酒精性脂肪肝病(NAFLD),更具體地非酒精性脂肪肝(NAFL)、非酒精性脂肪性肝炎(NASH)和/或NAFLD相關肝纖維化中的醫學用途。