Jeffrey I. Zink,Andre E. Nel,Tian Xia,Zhaoxia Ji,Huan Meng,Zongxi Li,Monty Liong,Min Xue,Derrick Y. Tarn,Sanaz Gardner
申请号：
US16427253
公开号：
US20190382265A1
申请日:
2019.05.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.
