Eric A. Kitas;David B. Rozema;Linda Valis;David L. Lewis;Ingo Roehl;Philipp Hadwiger;Darren H. Wakefield;Peter Mohr;Torsten Hoffmann
发明人:
Philipp Hadwiger,Torsten Hoffmann,Eric A. Kitas,Peter Mohr,Ingo Roehl,Linda Valis,David B. Rozema,David L. Lewis,Darren H. Wakefield
申请号：
US13327271
公开号：
US09249179B2
申请日:
2011.12.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.
