A method of obtaining symmetric temperature change, comprising the following steps of preparing a temperature sensing device； measuring and collecting temperature change: placing the temperature sensing device (1) on a predetermined position of a participant to measure and collect the participant's body temperature change data； extracting data； removing the temperature sensing device from the participant's body when running out of the battery and then connecting a reading device to extract the body temperature change data out of the temperature sensing device in order to apply the body temperature change data in precision medicine； the body temperature change data is used as the key marker without affecting the participant's daily activity, preventing the participant from inaccuracy of the body temperature change data caused by psychological and/or physiological factors, so the body temperature change data can be applied in the symmetry precision medicine.
