JOHN ROBERT POLLARD,PHILIP MICHAEL REAPER,MOHAMMED ASMAL
申请号：
HK15106842.0
公开号：
HK1206298A
申请日:
2015.07.17
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present invention relates to compounds useful as inhibitors of ATR protein kinase for use in the treatment of a cancer having a defect in the ATM signaling pathway. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of this invention and combination therapies thereof； use of said compounds in the treatment of various diseases, disorders, and conditions； processes for preparing the compounds of this invention； intermediates for the preparation of the compounds of this invention； and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena； the study of intracellular signal transduction pathways mediated by such kinases； and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein. Preferably, the compound is VE-822.
