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Methods of treating tumors with engineered antibody-interferon mutant fusion molecules
专利权人:
ImmunGene Inc.
发明人:
Iqbal Grewal,Sanjay Khare,Michael Gresser,Rashid Syed
申请号:
US14611945
公开号:
US09534057B2
申请日:
2015.02.02
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The field of the present invention relates to genetically engineered fusion molecules, methods of making said fusion molecules, and uses thereof in anti-tumor immunotherapies. More specifically, the present invention relates to fusion molecule constructs wherein a tumor associated antigen (TAA) antibody (Ab) serves as a targeting moiety to selectively deliver a cytokine to a tumor cell for purposes of killing or inhibiting the growth or proliferation of said tumor cell. In various embodiments, the engineered fusion molecules comprise a TAA Ab fused to an interferon-alpha (IFN-α) mutant molecule. The engineered Ab-IFN-α mutant fusion molecules of the present invention demonstrate improved therapeutic index and preserved or increased efficacy as compared to Ab-wildtype IFN-α fusion molecules, and/or demonstrate improved PK properties as compared to Ab-wildtype IFN-α fusion molecules.
来源网站:
中国工程科技知识中心
来源网址:
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