The Invention describes antiandrogens are selected from 4 - (6 - [7 - 5 - 3 - cyano - trifluorometilpiridin - yl) - 8 - 6 - oxo - tioxo 5.7 - diazaspiro [3,4] oct - il] - 2 - 5 - fluoro - n-methylbenzamide, 4 - (3 - (4 - cyano - 3 - (trifluoromethyl) phenyl) - 5,5 - dimethyl - 2 - 4 - oxo - il) tioxoimidazolidin - 1 - 2 - fluoro n-methylbenzamide, among others.These compounds are useful in the treatment of Castration resistant prostate cancer metastatic nonLa invencion se describe antiandrogenos que se selecciona de 4-[7-(6-ciano-5-trifluorometilpiridin-3-il)-8-oxo-6-tioxo-5,7-diazaspiro[3,4]oct-5-il]-2-fluoro-N-metilbenzamida, 4-(3-(4-ciano-3-(trifluorometil)fenil)-5,5-dimetil-4-oxo-2-tioxoimidazolidin-1-il)-2-fluoro-N-metilbenzamida, entre otros. Dichos compuestos son utiles en el tratamiento de cancer de prostata resistente a la castracion no metastasico
