The present invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to 1-phenyl-2-pyridinyl alkyl alcohol derivatives, to processes for the preparation thereof, compositions comprising them, combinations and therapeutic uses thereof.本發明係有關於磷酸二酯酶4(PDE4)酵素之抑制劑。更明確言之,本發明係有關於1-苯基-2-吡啶基烷基醇衍生物、其製備方法、包含該等化合物之組成物、其組合及其治療用途。