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Protein kinase B inhibitors
专利权人:
AstraZeneca AB
发明人:
Paul David Johnson,Andrew Leach,Richard William Arthur Luke,Zbigniew Stanley Matusiak,Jeffrey James Morris
申请号:
US15351481
公开号:
US10059714B2
申请日:
2016.11.15
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention relates to a novel group of compounds of Formula (I) or salts thereof:wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).
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