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Alkyl-heterocycle carbamate derivatives, their preparation and their therapeutic application
专利权人:
Ahmed Abouabdellah;Antoine Ravet
发明人:
Ahmed Abouabdellah,Antoine Ravet
申请号:
US13574188
公开号:
US09000010B2
申请日:
2011.01.19
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The invention relates to compounds corresponding to the general formula (I):in which R2 represents a hydrogen, fluorine, hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy or —NR8R9; n and m represent, independently of one another, an integer equal to 1, 2 or 3, it being understood that the sum m+n is at most equal to 5; A represents a covalent bond, an oxygen, a C1-6-alkylene or —O—C1-6-alkylene; R1 represents a phenyl or a heterocycle which is optionally substituted; R3 represents a hydrogen, fluorine, C1-6-alkyl or trifluoromethyl; R4 represents an optionally substituted 5-membered heterocycle; in the form of the base or of an addition salt with an acid; with the exclusion of 5-methylisoxazol-3-ylmethyl 4-hydroxy-4-(4-chlorophenyl)piperidine-1-carboxylate.The invention also relates to a process for the preparation of the compounds of formula (I), to compositions comprising them and to their therapeutic application.
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