The present invention relates to the field of cancer therapy. Specifically, provided are methods of treating cancer in a subject with a farnesyltransferase inhibitor (FTI) that include determining whether the subject is likely to be responsive to the FTI treatment based on the activity of the CXCL12/CXCR4 pathway, and/or the activity of the IGF1R pathway. Provided herein are also combination therapy of cancer treatment using FTI and either an IGF1R inhibitor or a CXCR4 antagonist.本發明係關於癌症療法之領域。具體而言，提供以法尼基轉移酶(farnesyltransferase)抑制劑(FTI)治療個體之癌症之方法，其包含基於CXCL12/CXCR4路徑之活性及/或IGF1R路徑之活性來測定該個體是否可能對該FTI治療有反應。本文亦提供使用FTI及IGF1R抑制劑或CXCR4拮抗劑之癌症治療之組合療法。
