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IN SITU GELLING ALGINATE SYSTEMS
专利权人:
发明人:
申请号:
EP10711941.4
公开号:
EP2416741A1
申请日:
2010.04.06
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention relates to a dispensing system that can be used to introduce a gel-forming fluid into or onto the body that will produce a homogeneous gel in situ. The system according to the present invention comprises: a first reservoir comprising a first flowable composition in the form of an aqueous solution of ionically cross-linkable alginate a second reservoir comprising a second flowable composition, said second flowable composition containing one or more polyols a first outlet from the first reservoir a second outlet from the second reservoir, said first outlet and said second outlet being arranged in such a way that the first flowable composition is mixed with the second flowable composition when both compositions are simultaneously expelled from the respective reservoirs thereby forming the gel- forming fluid wherein the first and/or second flowabel composition contains a cross- linking agent and upon admixture of the first flowable composition with the second flowable composition said cross-linking agent initiates the formation of a solid or semi-solid ionically cross- linked alginate gel. The presence of a substantial amount of polyol in the second flowable composition favourably affects the cross-linking reaction between the cross-linking agent and the alginate.
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