PROCÉDÉ DE PRÉPARATION DE N-(4-(6,7-DIMÉTHOXYQUINOLIN-4-YLOXY) PHÉNYL)-N'-(4-FLUOROPHÉNYL)CYCLOPROPANE-1, 1-DICARBOXAMIDE, (2S)-HYDROXYBUTANEDIOATE ET SES POLYMORPHES

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专利权人:

ESWARAIAH, Sajja;MSN LABORATORIES PRIVATE LIMITED;RAJESHAM, Boge;SHYAM KIRAN BABU, Gandham;THIRUMALAI RAJAN, Srinivasan;VENKATA PANAKALA RAO, Gogulapati; R&D CENTER;MSN LABORATORIES PRIVATE LIMITED, R&D CENTER;RAJESHWAR REDDY, Sagyam

发明人:

THIRUMALAI RAJAN, Srinivasan,ESWARAIAH, Sajja,VENKATA PANAKALA RAO, Gogulapati,RAJESHWAR REDDY, Sagyam,SHYAM KIRAN BABU, Gandham,RAJESHAM, Boge

申请号：

ININ2017/000139

公开号：

WO2018/104954A1

申请日:

2017.12.06

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N' -( 4-fluorophenyl)cyclopropane-1, 1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural.La présente invention concerne un procédé de préparation d'un composé de N-(4-(6,7-diméthoxy quinolin-4-yloxy)phényl)-N' -( 4-fluorophényl)cyclopropane-1, 1-dicarboxamide (S)-malate de formule -1a et ses polymorphes, représenté par la structure suivante.

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