METHODS OF TREATING MULTIPLE MYELOMA CANCERS EXPRESSING HIGH LEVELS OF EPO-RECEPTOR USING PSA-EPO

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专利权人:

Lipoxen Technologies Limited

发明人:

Dmitry Genkin

申请号：

US16608781

公开号：

US20200179524A1

申请日:

2018.04.25

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention demonstrates that erythropoietin (EPO)-receptor (EPOR) is a malignant myeloma biomarker of sensitivity to EPO treatment and, itself a target for myeloma treatment. A low EPOR level in a myeloma cells of the subject indicates non-response to EPO treatment. Patients having high EPOR level in myeloma cells can be effectively treated with EPO, in particular an EPO derivatized with polysialic acid.

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