The present invention relates to a composition containing extracts of polytrichastrum alpinum for preventing or treating arteriosclerosis. More particularly, the present invention relates to a pharmaceutical composition containing, as an active ingredient, ohioensins F which is a benzonaphthoxanthenone-based compound separated from Antarctic lichens polytrichastrum alpinum, for preventing or treating arteriosclerosis. The composition containing ohioensins F which is a benzonaphthoxanthenone-based compound derived from polytrichastrum alpinum according to the present invention may inhibit an expression of cell adhesion molecules induced by TNF-α, and therefore, can be valuably used in treating and preventing arteriosclerosis.La présente invention concerne une composition contenant des extraits de polytrichastrum alpinum pour prévenir ou traiter lartériosclérose. Plus particulièrement, la présente invention concerne une composition pharmaceutique contenant, en tant que principe actif, de lohioensine F qui est un composé à base de benzonaphthoxanthenone dérivé de lichens dAntarctique polytrichastrum alpinum, pour prévenir ou traiter lartériosclérose. La composition contenant lohioensine F, un composé à base de benzonaphthoxanthenone dérivé de polytrichastrum alpinum, peut inhiber une expression des molécule dadhésion cellulaire induite par TNF-α, et de ce fait, elle peut être avantageusement utilisée pour traiter et prévenir lartériosclérose.본 발명은 폴리트리카스트럼 알피넘 추출물을 함유하는 동맥경화증 예방 또는 치료용 조성물에 관한 것으로, 보다 상세하게는 남극 이끼류인 폴리트리카스트럼 알피넘으로부터 분리된 벤조나프토크산테논계 화합물 오하이오넨신 F를 유효성분으로 함유하는 동맥경화증 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 폴리트리카스트럼 알피넘(Polytrichastrum alpinum) 추출물 유래 벤조나프토크산테논계 화합물 오하이오넨신 F가 함유된 조성물은 TNF-α에 의해 유도되는 세포부착분자의 발현을 억제시킴으로써, 동맥경화증 치료 및 예방에 유용하게 사용할 수 있다.
