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שימושים בנוגדנים נוגדי–tnfalpha לייצור תרופה מותאמת למתן תת עורי דו שבועי, ערכות המכילות אותם ומזרקים טעונים מראש המכילים אותם
专利权人:
ABBVIE BIOTECHNOLOGY LTD.
发明人:
申请号:
IL15883103
公开号:
IL158831A
申请日:
2003.11.11
申请国别(地区):
IL
年份:
2014
代理人:
摘要:
Methods of treating disorders in which TNF± activity is detrimental via biweekly, subcutaneous administration of human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor ± (hTNF ±) are disclosed. The antibody may be administered with or without methotrexate. These antibodies have high affinity for hTNF± (e.g., K d = 10 -8 M or less), a slow off rate for hTNF± dissociation (e.g., K off = 10 -3 sec -1 or less) and neutralize hTNF± activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Kits containing a pharmaceutical composition and instructions for dosing, and preloaded syringes containing pharmaceutical compositions are also encompassed by the invention.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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