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Derivatives of 2-pyridin-2-yl-pyrazol-3 (2H) -one, its preparation and therapeutic use as activators of HIF
专利权人:
SANOFI
发明人:
ALTENBURGER, JEAN-MICHEL,FOSSEY, VALÉRIE,ILLIANO, STÉPHANE,MANETTE, GÉRALDINE
申请号:
ES09805789
公开号:
ES2481042T3
申请日:
2009.12.24
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compound that responds to the following formula (I): in which R represents a group -SO2-NR3R4 or a group -SO2-R4; R3, R4 and R5 being as defined below; R1 represents a heterocycloalkyl group that does not contain a nitrogen atom, a -W-cycloalkyl (C3-C6) group, a -W-aryl group, a -W-heteroaryl group, a -W-heterocycloalkyl group, a -W- group COOR5 or a -W-CONR5R6 group, (i) said aryl, heteroaryl and heterocycloalkyl groups being optionally substituted on at least one carbon atom with at least one substituent selected from the halogen atoms, the (C1-C5) alkyl groups, C1-C5-alkylene-C1-C5-alkyl groups, C1-C5 alkoxy groups, hydroxy function, C1-C5 halogenoalkyl groups, cyano function, groups O-C1-C5 alkylene-O-C1-C5 alkyl, -O-C1-C5-alkylene-NR5R6 groups, C1-C5 alkyl-SO2-groups, -NR5R6 groups and groups - CO2R5, and (ii) it being understood that when it is a heterocycloalkyl group, said group comprises at least one nitrogen atom, the latter may optionally contain a substituent selected from the (C1-C5) alkyl groups, R2 re it has a hydrogen atom, a (C1-C5) alkyl group, a (C1-C5) alkylene-O (C1-C5) alkyl group, a (C1-C5) halogenoalkyl group, a -W- group COOR5, a group -WC (O) NHR5 or a group -WC (O) -NR5R6; where W, R5 and R6 are as defined below; it being understood that: or n represents 0, 1 or 2; or W is (i) a (C1-C5) alkylene group -, optionally substituted with a group selected from the groups - (CH2) n-CO2R5 and the groups - (CH2) n- (CO) NR5R6, with n such as defined above and R5 and R6 as defined below; or (ii) a (C3-C6) cycloalkylene group -, or R3 and R4.Compuesto que responde a la fórmula (I) siguiente: en la que R representa un grupo -SO2-NR3R4 o un grupo -SO2-R4; siendo R3, R4 y R5 tales como se definen a continuación; R1 representa un grupo heterocicloalquilo que no contiene átomo de nitrógeno, un grupo -W-cicloalquilo(C3-C6), un grupo -W-arilo, un grupo -W-heteroarilo, un grupo -W-heterocicloalquilo, un grupo -W-COOR5 o un grupo -W-CONR5R6, (i) estando dichos
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