Methods for reducing, inhibiting or preventing cancer metastasis comprise blocking the movement of mitochondria within a cancer cell. Other methods involve interrupting or preventing oxidative phosphorylation pathways or respiration pathways in the cancer cell. In one embodiment, mitochondrial movement is induced by contact of the cell with PI3K inhibitors or antagonists. Methods for treating cancer involve a regimen of treating a subject with a PI3K inhibitor or antagonist and treating the subject with a composition that blocks the movement of mitochondria within the subject's cells.
