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MUTATION DU GENE DE LA MYOSTATINE A L'ORIGINE DE L'HYPERTROPHIE MUSCULAIRE CHEZ LES MAMMIFERES
专利权人:
UNIVERSITY OF LIEGE
发明人:
GROBET, LUC,GEORGES, MICHEL,PONCELET, DOMINIQUE
申请号:
CA2296434
公开号:
CA2296434C
申请日:
1998.07.14
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
A gene (cDNA) encoding a bovine myostatin protein. The nucleic acid coding sequence is identified as SEQ ID NO:1 and the protein sequence is identified as SEQ ID NO:2. A mutant gene (SEQ ID NO:3) in which the coding sequence lacks an 11-base pair consecutive sequence (SEQ ID NO:11) of the sequence encoding bovine protein having myostatin activity has been sequenced. It has been shown that cattle of the Belgian Blue breed homozygous for the mutant gene lacking myostatin activity are double-muscled. A method for determining the presence of muscular hyperplasia in a mammal is described. The method includes obtaining a sample of material containing DNA from the mammal and ascertaining whether a sequence of the DNA encoding (a) a protein having biological activity of myostatin, is present, and whether a sequence of the DNA encoding (b) an allelic protein lacking the activity of (a), is present. The absence of (a) and the presence of (b) indicates the presence of muscular hyperplasia in the mammal.
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