The present invention relates to a composition comprising 3-hydroxy phloretin (3-OH phloretin) as an active ingredient for preventing or treating obesity. A composition comprising 3-hydroxy phloretin or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating obesity according to the present invention effectively inhibits PPARγ (peroxisome proliferator-activated receptor γ), C/EBPα (CCAAT/enhancer-binding protein α), and fatty acid synthase, which are adipocyte differentiation-promoting factors, to reduce lipid contents in cells. Thus, the composition is expected to find wide applications in the prevention or treatment of obesity.La présente invention concerne une composition comprenant la 3-hydroxy-phlorétine (3-OH-phlorétine) utilisée comme principe actif pour la prévention ou le traitement de l'obésité. Une composition comprenant la 3-hydroxy-phlorétine, ou un sel pharmaceutiquement acceptable de celle-ci, utilisée comme principe actif pour la prévention ou le traitement de l'obésité selon la présente invention inhibe efficacement le PPARγ (récepteur γ activé par les proliférateurs de peroxisomes), la C/EBPα (protéine α se fixant sur la séquence activatrice CCAAT), et l'acide gras synthase, qui sont des facteurs favorisant la différenciation des adipocytes, pour réduire la teneur des lipides dans les cellules. Ainsi, la composition est censée trouver de larges applications dans la prévention ou le traitement de l'obésité.본 발명은 3-하이드록시 플로레틴(3-hydroxy phloretin, 3-OH phloretin)을 유효성분으로 함유하는 비만 예방 또는 치료용 조성물에 관한 것으로, 본 발명에 따른 3-하이드록시 플로레틴 또는 이의 약학적으로 허용 가능한 염을 유효 성분으로 함유하는 비만 예방 또는 치료용 조성물은 주요한 지방 분화 촉진 인자인 PPARγ (peroxisome proliferator-activated receptor γ), C/EBPα (CCAAT/enhancer-binding protein α) 및 지방산 합성 효소(fatty acid synthase) 등을 효과적으로 억제하여 세포 내 지방 함량을 감소시켜 비만의 예방 또는 치료를 위해 널리 활용될 수 있을 것으로 기대된다.
