The stress detection and management includes a human interface device having a mouse portion to generate cursor control signals and a stress detection portion. The stress detection portion includes a plurality of sensor probes to detect a user's electrical skin response to stress. A sensor is coupled to the plurality of sensor probes to generate a voltage indicative of the skin response to stress. A neural network, coupled to the sensor, generates a stress classification indication based on the voltage indicative of the skin response and pre-training of the neural network with stress indications. The neural network is retrained by comparing the baseline stress classification with the user inputs, using heuristic rules.