William DEGRADO,David M. TELLERS,Gevorg GRIGORYAN,Vasant JADHAV,Yao ZHANG
申请号：
US14768207
公开号：
US20150374844A1
申请日:
2014.02.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed herein is a pH-switchable pore formation (PSPF) peptide comprising one or more amino acids in peptide sequence whose charge state and hydrophobicity are pH-dependent, wherein the peptide can bind to a biological membrane upon contact and form pores on the membrane at pH of less than about 7, and wherein the peptide forms substantially no pores on the biological membrane at pH of greater than about 7. Also disclosed is a modular composition comprising: a) one or more PSPF peptides, which may be the same or different b) a single stranded or double stranded oligonucleotide and c) one or more linkers, which may be the same or different.
