The Broad Institute, Inc.;The General Hospital Corporation d/b/a Massachusetts General Hospital;President and Fellows of Harvard College;Dana-Farber Cancer Institute, Inc.
发明人:
Alykhan Shamji,Thomas Sundberg,Nathanael S. Gray,Ramnik Xavier,Stuart L. Schreiber,Hwan Geun Choi,Yanke Liang
申请号：
US16389641
公开号：
US20190343842A1
申请日:
2019.04.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as macrocyclic SIK inhibitors of Formula (I), imidazolyl SIK inhibitors of Formula (II), and urea and carbamate SIK inhibitors of Formula (III-A) (e.g., urea and carbamate STK inhibitors of Formula (III)).
