KENNEDY NICHOLAS,GAVIN PAUL DAVID,EL-TAMIMY MAHMOUD,GAETANO GIACINTO,COTTRELL JEREMY
申请号：
NZ60257211
公开号：
NZ602572A
申请日:
2011.03.30
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed herein is a matrix layer suitable for use in a transdermal delivery patch for administration of a biologically active compound, the matrix layer comprising a mixture of a mono-tocopheryl phosphate compound and a di-tocopheryl phosphate compound and a polymer carrier comprising polymers selected from the group consisting of polyacrylates, rubber-based polymers, polysiloxanes and 5 amine-resistant polysiloxanes, wherein the polymer carrier is present in an amount within the range of about 30%w/w to about 95%w/w of the total concentration of the matrix layer, and wherein the mono-tocopheryl phosphate compound is selected from the group consisting of mono-(tocopheryl) phosphate, mono-(tocopheryl) phosphate monosodium salt, mono-(tocopheryl) phosphate disodium salt, mono-(tocopheryl) phosphate monopotassium salt and mono-(tocopheryl) phosphate dipotassium salt, and the di-tocopheryl phosphate compound is selected from the group consisting of di-(tocopheryl) phosphate, di-(tocopheryl) phosphate monosodium salt and di-(tocopheryl) phosphate monopotassium salt, and wherein the polymer carrier further comprises inert carrier components selected from the group consisting of anti-tacking agents, tackifiers, and plasticizers.
