It does not join to A monomer, it contains the human conversion antibody and the said antibody which are joined to only the A oligomer uniquely, as the active ingredient the amyloid protein oligomer which is thought as the cause protein of the anti- acknowledgment dysfunction medicine Alzheimers disease (the A oligomer) it joins uniquely, the antibody medicine which can remedy the Alzheimers disease is required. With this invention, it is possible to offer the remedy manner of the Alzheimers disease which uses the anti- A oligomer human conversion antibody and the said human conversion antibody which the A oligomer uniquely are joined. The Alzheimers disease remedy medicine, the senile plaque formation restrainer or the A amyloid tissue formation inhibiter, the process which prescribes the said antibody is included, the manner which includes at least the manner for one side of acknowledgment dysfunction or prevention and remedy, of the Alzheimers disease, and the process which prescribes the said antibody suppresses the advance of the Alzheimers disease.Aβモノマーに結合せず、Aβオリゴマーのみに特異的に結合するヒト化抗体、該抗体を有効成分として含有する、抗認知機能障害剤アルツハイマー病の原因タンパク質として考えられているアミロイドβタンパク質オリゴマー(Aβオリゴマー)に特異的に結合し、アルツハイマー病を治療できる抗体医薬が求められている。本発明により、Aβオリゴマー特異的に結合する抗Aβオリゴマーヒト化抗体、該ヒト化抗体を用いたアルツハイマー病の治療方法を提供することができる。、アルツハイマー病治療剤、老人斑形成抑制剤またはAβアミロイド線維形成阻害剤、該抗体を投与する工程を含む、認知機能障害またはアルツハイマー病の予防および治療の少なくとも一方のための方法、並びに該抗体を投与する工程を含む、アルツハイマー病の進行を抑制する方法。
