Improved devices, systems and methods for the expression of milk from a breast are disclosed herein. A device for expression of milk may comprise a peristaltic pump configured to move a fluid to or from a breast interface, so as to apply pressure at the breast interface and thereby express milk from the breast. The peristaltic pump can be removably coupled to a tube carrying the fluid, so as to maintain a separation between the peristaltic pump and the fluidly coupled components of the device. A device for expressing breast milk may further comprise an adjustable breast interface configured to engage and fluidly seal against the human breast. The adjustable breast interface may be manually or automatically adjustable to fluidly seal against a plurality of sizes or shapes of human breasts.
