607636 Disclosed is a composition, the composition including a therapeutically effective amount of at least one active agent, and a base configured to provide a controlled release of the at least one active agent, the base including, an amount of colloidal silica at least one oil and at least one surfactant, wherein the viscosity of the composition is below 1000 mPas at a shear rate of 100 1/s and at a temperature of 20°C. Also disclosed is the method for preparing the composition, the method of treating a non-human animal for mastitis and the use of the composition for the manufacture of a medicament for treating mastitis.