Elena A. Goun,Aurélien Godinat,Aleksey Yevtodiyenko
申请号：
US15944714
公开号：
US20180280542A1
申请日:
2018.04.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A system for monitoring biological processes in vivo is provided. The system comprises an implantable luciferase biosensor comprising luciferase in a biocompatible matrix and a caged luciferin probe. The caged luciferin probe can be administered to a living subject and upon encountering a biological activity, e.g., enzyme activity, the caged luciferin probe releases free luciferin which can then interact with the biosensor luciferase to generate light. The light can then be detected and/or measured by a light detector. Compositions, methods and kits related to the system are provided herein.
