Single monomer derived linear-like copolymer comprising polyethylenimine and poly(ethylene glycol) for nucleic acid delivery

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专利权人:

Shu-Yi Lin

发明人:

Shu-Yi Lin,Chung-Shi Yang,Yeu-Kuang Hwu

申请号：

US13041023

公开号：

US08461224B2

申请日:

2011.03.04

申请国别(地区):

US

年份:

2013

代理人:

摘要：

A method of synthesizing a random copolymer of polyethyleneimine and polyethylene glycol, comprising exposing ethanolamine in a solution to electromagnetic radiation for a sufficient time to polymerize the ethanolamine (OHCH2CH2NH2) and thereby resulting in formation of the randome copolymer comprising polyethyleneimine and poly(ethylene glycol), wherein the polyethyleneimine comprises ethyleneimine (—CH2CH2NH—) unit and the polyethylene glycol comprises ethylene glycol (—CH2CH2O—) unit, and the polyethylenimine of the random copolymer has a substantially linear backbone.

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